A high rate of polymerization during synthesis of mouse mammary tumor virus DNA alleviates hypermutation by APOBEC3 proteins

Retroviruses have evolved multiple means to counteract host restriction factors such as single-stranded DNA-specific deoxycytidine deaminases (APOBEC3s, A3s). These include exclusion of A3s from virions by an A3-unreactive nucleocapsid or expression of an A3-neutralizing protein (Vif, Bet). However,...

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Detalles Bibliográficos
Autores principales: Hagen, Benedikt, Kraase, Martin, Indikova, Ivana, Indik, Stanislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395001/
https://www.ncbi.nlm.nih.gov/pubmed/30768644
http://dx.doi.org/10.1371/journal.ppat.1007533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395001/
https://www.ncbi.nlm.nih.gov/pubmed/30768644
http://dx.doi.org/10.1371/journal.ppat.1007533

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