Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we present single-particle cryo-electron microscopy stru...

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Detalles Bibliográficos
Autores principales: Kern, David M, Oh, SeCheol, Hite, Richard K, Brohawn, Stephen G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395065/
https://www.ncbi.nlm.nih.gov/pubmed/30775971
http://dx.doi.org/10.7554/eLife.42636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395065/
https://www.ncbi.nlm.nih.gov/pubmed/30775971
http://dx.doi.org/10.7554/eLife.42636

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