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Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A
Single missense mutations in the F8 gene encoding the coagulation protein factor VIII give rise predominantly to non-severe hemophilia A. Despite only a single amino acid sequence difference between the replacement, therapeutic factor VIII and the patient’s endogenous factor VIII, therapeutic factor...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395325/ https://www.ncbi.nlm.nih.gov/pubmed/30266735 http://dx.doi.org/10.3324/haematol.2018.195669 |