Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A

Single missense mutations in the F8 gene encoding the coagulation protein factor VIII give rise predominantly to non-severe hemophilia A. Despite only a single amino acid sequence difference between the replacement, therapeutic factor VIII and the patient’s endogenous factor VIII, therapeutic factor...

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Detalles Bibliográficos
Autores principales: Hart, Daniel P., Uzun, Nazmiye, Skelton, Stuart, Kakoschke, Alison, Househam, Jacob, Moss, David S., Shepherd, Adrian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395325/
https://www.ncbi.nlm.nih.gov/pubmed/30266735
http://dx.doi.org/10.3324/haematol.2018.195669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395325/
https://www.ncbi.nlm.nih.gov/pubmed/30266735
http://dx.doi.org/10.3324/haematol.2018.195669

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