CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth

Classic Hodgkin lymphoma tumor cells express a functional CCR5 receptor, and tumor tissues express high CCL5 levels, suggesting that CCL5-CCR5 signaling is involved in tumor-microenvironment formation and tumor growth. Using the CCR5 antagonist, maraviroc, and a neutralizing anti-CCL5 antibody, we f...

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Detalles Bibliográficos
Autores principales: Casagrande, Naike, Borghese, Cinzia, Visser, Lydia, Mongiat, Maurizio, Colombatti, Alfonso, Aldinucci, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395337/
https://www.ncbi.nlm.nih.gov/pubmed/30309853
http://dx.doi.org/10.3324/haematol.2018.196725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395337/
https://www.ncbi.nlm.nih.gov/pubmed/30309853
http://dx.doi.org/10.3324/haematol.2018.196725

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