In vivo RNA editing of point mutations via RNA-guided adenosine deaminases

We utilized a system for sequence-specific RNA base editing via Adenosine Deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). We systematically engineered it to harness ADARs, and comprehensively evaluated its specificity and activity in vitro and in vivo via two mouse...

Descripción completa

Detalles Bibliográficos
Autores principales: Katrekar, Dhruva, Chen, Genghao, Meluzzi, Dario, Ganesh, Ashwin, Worlikar, Atharv, Shih, Yu-Ru, Varghese, Shyni, Mali, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395520/
https://www.ncbi.nlm.nih.gov/pubmed/30737497
http://dx.doi.org/10.1038/s41592-019-0323-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395520/
https://www.ncbi.nlm.nih.gov/pubmed/30737497
http://dx.doi.org/10.1038/s41592-019-0323-0

Ejemplares similares