CRISPR-mediated activation of endogenous BST-2/tetherin expression inhibits wild-type HIV-1 production

The CRISPR technology not only can knock out target genes by using the RNA-guided Cas9 nuclease but also can activate their expression when a nuclease-deficient Cas9 (dCas9) is employed. Using the latter function, we here show the effect of the CRISPR-mediated pinpoint activation of endogenous expre...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yanzhao, Ozono, Seiya, Yao, Weitong, Tobiume, Minoru, Yamaoka, Shoji, Kishigami, Satoshi, Fujita, Hideaki, Tokunaga, Kenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395588/
https://www.ncbi.nlm.nih.gov/pubmed/30816279
http://dx.doi.org/10.1038/s41598-019-40003-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395588/
https://www.ncbi.nlm.nih.gov/pubmed/30816279
http://dx.doi.org/10.1038/s41598-019-40003-z

Ejemplares similares