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CRISPR-mediated activation of endogenous BST-2/tetherin expression inhibits wild-type HIV-1 production
The CRISPR technology not only can knock out target genes by using the RNA-guided Cas9 nuclease but also can activate their expression when a nuclease-deficient Cas9 (dCas9) is employed. Using the latter function, we here show the effect of the CRISPR-mediated pinpoint activation of endogenous expre...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395588/ https://www.ncbi.nlm.nih.gov/pubmed/30816279 http://dx.doi.org/10.1038/s41598-019-40003-z |