A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green

Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to no...

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Autores principales: Inagaki, Yoshinori, Kokudo, Takashi, Kamiya, Mako, Uno, Shin-nosuke, Sato, Masumitsu, Kaneko, Junichi, Kokudo, Norihiro, Urano, Yasuteru, Hasegawa, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395603/
https://www.ncbi.nlm.nih.gov/pubmed/30816163
http://dx.doi.org/10.1038/s41598-019-39269-0
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author Inagaki, Yoshinori
Kokudo, Takashi
Kamiya, Mako
Uno, Shin-nosuke
Sato, Masumitsu
Kaneko, Junichi
Kokudo, Norihiro
Urano, Yasuteru
Hasegawa, Kiyoshi
author_facet Inagaki, Yoshinori
Kokudo, Takashi
Kamiya, Mako
Uno, Shin-nosuke
Sato, Masumitsu
Kaneko, Junichi
Kokudo, Norihiro
Urano, Yasuteru
Hasegawa, Kiyoshi
author_sort Inagaki, Yoshinori
collection PubMed
description Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to normal cells and it had superior anti-tumor action compared to gemcitabine alone in a subcutaneous tumor xenograft. ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC.
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spelling pubmed-63956032019-03-04 A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green Inagaki, Yoshinori Kokudo, Takashi Kamiya, Mako Uno, Shin-nosuke Sato, Masumitsu Kaneko, Junichi Kokudo, Norihiro Urano, Yasuteru Hasegawa, Kiyoshi Sci Rep Article Indocyanine green (ICG) accumulates only in hepatocytes and their malignant counterpart, hepatocellular carcinoma (HCC). We have developed ICG-conjugated anti-cancer drugs and noted their significant accumulation in HCC cells both in vitro and in vivo. ICG-conjugated gemcitabine was less toxic to normal cells and it had superior anti-tumor action compared to gemcitabine alone in a subcutaneous tumor xenograft. ICG conjugation can provide a novel fluorescent drug delivery system for treatment of liver cancer and this system can be used to both diagnose and treat HCC. Nature Publishing Group UK 2019-02-28 /pmc/articles/PMC6395603/ /pubmed/30816163 http://dx.doi.org/10.1038/s41598-019-39269-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Inagaki, Yoshinori
Kokudo, Takashi
Kamiya, Mako
Uno, Shin-nosuke
Sato, Masumitsu
Kaneko, Junichi
Kokudo, Norihiro
Urano, Yasuteru
Hasegawa, Kiyoshi
A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title_full A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title_fullStr A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title_full_unstemmed A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title_short A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
title_sort novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395603/
https://www.ncbi.nlm.nih.gov/pubmed/30816163
http://dx.doi.org/10.1038/s41598-019-39269-0
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