Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level

Human cells are stressed by numerous mechanisms that can lead to leakage of mitochondrial DNA (mtDNA) to the cytoplasm and ultimately apoptosis. This agonist DNA constitutes a danger to the cell and is counteracted by cytoplasmic DNases and APOBEC3 cytidine deamination of DNA. To investigate APOBEC3...

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Detalles Bibliográficos
Autores principales: Mussil, Bianka, Suspène, Rodolphe, Caval, Vincent, Durandy, Anne, Wain-Hobson, Simon, Vartanian, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395610/
https://www.ncbi.nlm.nih.gov/pubmed/30816165
http://dx.doi.org/10.1038/s41598-019-39245-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395610/
https://www.ncbi.nlm.nih.gov/pubmed/30816165
http://dx.doi.org/10.1038/s41598-019-39245-8

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