Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation

Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacologic...

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Detalles Bibliográficos
Autores principales: Castellví, Albert, Crespo, Isidro, Crosas, Eva, Cámara-Artigas, Ana, Gavira, José A., Aranda, Miguel A. G., Parés, Xavier, Farrés, Jaume, Juanhuix, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395642/
https://www.ncbi.nlm.nih.gov/pubmed/30816220
http://dx.doi.org/10.1038/s41598-019-39722-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395642/
https://www.ncbi.nlm.nih.gov/pubmed/30816220
http://dx.doi.org/10.1038/s41598-019-39722-0

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