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Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation
Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacologic...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395642/ https://www.ncbi.nlm.nih.gov/pubmed/30816220 http://dx.doi.org/10.1038/s41598-019-39722-0 |