A T7 autogene-based hybrid mRNA/DNA system for long-term shRNA expression in cytoplasm without inefficient nuclear entry

The transient silencing effects currently demonstrated by nonviral siRNA delivery systems limit the therapeutic utility of RNAi, but it remains a technical challenge to prolong duration of gene silencing. We have developed a T7 autogene-based hybrid mRNA/DNA system to enable long-term expression of...

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Detalles Bibliográficos
Autores principales: Kwak, Seo Young, Han, Hee Dong, Ahn, Hyung Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395690/
https://www.ncbi.nlm.nih.gov/pubmed/30816180
http://dx.doi.org/10.1038/s41598-019-39407-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395690/
https://www.ncbi.nlm.nih.gov/pubmed/30816180
http://dx.doi.org/10.1038/s41598-019-39407-8

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