Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase lon...

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Detalles Bibliográficos
Autores principales: Nguyen, Nga N., Rana, Anil, Goldman, Camille, Moore, Rhiannon, Tai, Justin, Hong, Yongchan, Shen, Jingyi, Walker, David W., Hur, Jae H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395709/
https://www.ncbi.nlm.nih.gov/pubmed/30816680
http://dx.doi.org/10.1038/s41598-019-39508-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395709/
https://www.ncbi.nlm.nih.gov/pubmed/30816680
http://dx.doi.org/10.1038/s41598-019-39508-4

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