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Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
The β5 subunit of the proteasome has been shown in worms and in human cell lines to be regulatory. In these models, β5 overexpression results in upregulation of the entire proteasome complex which is sufficient to increase proteotoxic stress resistance, improve metabolic parameters, and increase lon...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395709/ https://www.ncbi.nlm.nih.gov/pubmed/30816680 http://dx.doi.org/10.1038/s41598-019-39508-4 |