Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) promotes the aggressiveness of human uveal melanoma through dephosphorylation of CRMP2

Uveal melanoma (UM) is an aggressive tumor in which approximately 50% of patients develop metastasis. Expression of the PTP4A3 gene, encoding a phosphatase, is predictive of poor patient survival. PTP4A3 expression in UM cells increases their migration in vitro and invasiveness in vivo. Here, we sho...

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Detalles Bibliográficos
Autores principales: Duciel, Laura, Anezo, Océane, Mandal, Kalpana, Laurent, Cécile, Planque, Nathalie, Coquelle, Frédéric M., Gentien, David, Manneville, Jean-Baptiste, Saule, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395723/
https://www.ncbi.nlm.nih.gov/pubmed/30816227
http://dx.doi.org/10.1038/s41598-019-39643-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395723/
https://www.ncbi.nlm.nih.gov/pubmed/30816227
http://dx.doi.org/10.1038/s41598-019-39643-y

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