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Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters

The biosynthetic machinery responsible for the production of bacterial specialised metabolites is encoded by physically clustered group of genes called biosynthetic gene clusters (BGCs). The experimental characterisation of numerous BGCs has led to the elucidation of subclusters of genes within BGCs...

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Detalles Bibliográficos
Autores principales: Del Carratore, Francesco, Zych, Konrad, Cummings, Matthew, Takano, Eriko, Medema, Marnix H., Breitling, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395733/
https://www.ncbi.nlm.nih.gov/pubmed/30854475
http://dx.doi.org/10.1038/s42003-019-0333-6