Targeting NAD(+) Metabolism as Interventions for Mitochondrial Disease

Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse model of Leigh syndrome, we found that Complex I defic...

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Detalles Bibliográficos
Autores principales: Lee, Chi Fung, Caudal, Arianne, Abell, Lauren, Nagana Gowda, G. A., Tian, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395802/
https://www.ncbi.nlm.nih.gov/pubmed/30816177
http://dx.doi.org/10.1038/s41598-019-39419-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395802/
https://www.ncbi.nlm.nih.gov/pubmed/30816177
http://dx.doi.org/10.1038/s41598-019-39419-4

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