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Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration

Pulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone morphogenetic protein antagonist Gremlin 1 in this process; however, little is...

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Detalles Bibliográficos
Autores principales: de Jesus, Daniel S., DeVallance, Evan, Li, Yao, Falabella, Micol, Guimaraes, Danielle, Shiva, Sruti, Kaufman, Brett A., Gladwin, Mark T., Pagano, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395885/
https://www.ncbi.nlm.nih.gov/pubmed/30802716
http://dx.doi.org/10.1016/j.redox.2019.101138