Target-Specific Precision of CRISPR-Mediated Genome Editing

The CRISPR-Cas9 system has successfully been adapted to edit the genome of various organisms. However, our ability to predict the editing outcome at specific sites is limited. Here, we examined indel profiles at over 1,000 genomic sites in human cells and uncovered general principles guiding CRISPR-...

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Detalles Bibliográficos
Autores principales: Chakrabarti, Anob M., Henser-Brownhill, Tristan, Monserrat, Josep, Poetsch, Anna R., Luscombe, Nicholas M., Scaffidi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395888/
https://www.ncbi.nlm.nih.gov/pubmed/30554945
http://dx.doi.org/10.1016/j.molcel.2018.11.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395888/
https://www.ncbi.nlm.nih.gov/pubmed/30554945
http://dx.doi.org/10.1016/j.molcel.2018.11.031

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