Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison

The introduction of azole heterocycles into a peptide backbone is the principal step in the biosynthesis of numerous compounds with therapeutic potential. One of them is microcin B17, a bacterial topoisomerase inhibitor whose activity depends on the conversion of selected serine and cysteine residue...

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Detalles Bibliográficos
Autores principales: Ghilarov, Dmitry, Stevenson, Clare E.M., Travin, Dmitrii Y., Piskunova, Julia, Serebryakova, Marina, Maxwell, Anthony, Lawson, David M., Severinov, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395948/
https://www.ncbi.nlm.nih.gov/pubmed/30661981
http://dx.doi.org/10.1016/j.molcel.2018.11.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395948/
https://www.ncbi.nlm.nih.gov/pubmed/30661981
http://dx.doi.org/10.1016/j.molcel.2018.11.032

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