Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Cellular mechanisms that safeguard genome integrity are often subverted in cancer. To identify cancer-related genome caretakers, we employed a convergent multi-screening strategy coupled to quantitative image-based cytometry and ranked candidate genes according to multivariate readouts reflecting vi...

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Detalles Bibliográficos
Autores principales: Teloni, Federico, Michelena, Jone, Lezaja, Aleksandra, Kilic, Sinan, Ambrosi, Christina, Menon, Shruti, Dobrovolna, Jana, Imhof, Ralph, Janscak, Pavel, Baubec, Tuncay, Altmeyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395949/
https://www.ncbi.nlm.nih.gov/pubmed/30639241
http://dx.doi.org/10.1016/j.molcel.2018.11.036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395949/
https://www.ncbi.nlm.nih.gov/pubmed/30639241
http://dx.doi.org/10.1016/j.molcel.2018.11.036

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