Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors

Camptothecin (CPT), a natural product and its synthetic derivatives exert potent anticancer activity by selectively targeting DNA Topoisomerase I (Top1) enzyme. CPT and its clinically approved derivatives are used as Top1 poisons for cancer therapy suffer from many limitations related to stability a...

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Detalles Bibliográficos
Autores principales: Pal, Sourav, Kumar, Vinay, Kundu, Biswajit, Bhattacharya, Debomita, Preethy, Nagothy, Reddy, Mamindla Prashanth, Talukdar, Arindam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396084/
https://www.ncbi.nlm.nih.gov/pubmed/30867893
http://dx.doi.org/10.1016/j.csbj.2019.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396084/
https://www.ncbi.nlm.nih.gov/pubmed/30867893
http://dx.doi.org/10.1016/j.csbj.2019.02.006

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