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Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice
INTRODUCTION: Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevan...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396100/ https://www.ncbi.nlm.nih.gov/pubmed/30859123 http://dx.doi.org/10.1016/j.trci.2019.01.003 |