Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice

INTRODUCTION: Sleep disruption is a characteristic of Alzheimer's disease (AD) that may exacerbate disease progression. This study tested whether a dual orexin receptor antagonist (DORA) would enhance sleep and attenuate neuropathology, neuroinflammation, and cognitive deficits in an AD-relevan...

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Detalles Bibliográficos
Autores principales: Duncan, Marilyn J., Farlow, Hannah, Tirumalaraju, Chairtra, Yun, Do-Hyun, Wang, Chanung, Howard, James A., Sanden, Madison N., O'Hara, Bruce F., McQuerry, Kristen J., Bachstetter, Adam D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396100/
https://www.ncbi.nlm.nih.gov/pubmed/30859123
http://dx.doi.org/10.1016/j.trci.2019.01.003

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