Cargando…

Solution Structure of a MYC Promoter G-Quadruplex with 1:6:1 Loop Length

[Image: see text] The important MYC oncogene is deregulated in many cancer cells and comprises one of the most prominent G-quadruplex (G4) forming sequences in its promoter regions, the NHE III(1) motif. Formation of G4s suppresses MYC transcription and can be modulated by drug binding, establishing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dickerhoff, Jonathan, Onel, Buket, Chen, Luying, Chen, Yuwei, Yang, Danzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396123/ https://www.ncbi.nlm.nih.gov/pubmed/30842981 http://dx.doi.org/10.1021/acsomega.8b03580

Ejemplares similares

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Evaluating Molecular Docking Software for Small Molecule Binding to G-Quadruplex DNA
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

Sugar Puckering Drives G‐Quadruplex Refolding: Implications for V‐Shaped Loops
por: Haase, Linn, et al.
Publicado: (2019)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability
por: Mathad, Raveendra I., et al.
Publicado: (2011)

Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres
por: Wu, Guanhui, et al.
Publicado: (2019)

Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition
por: Liu, Wenting, et al.
Publicado: (2019)

G-Quadruplex DNA and RNA
por: Yang, Danzhou
Publicado: (2019)

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K(+) Solution
por: Agrawal, Prashansa, et al.
Publicado: (2014)

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
por: Dai, Jixun, et al.
Publicado: (2006)

G-quadruplex conformation and dynamics are determined by loop length and sequence
por: Tippana, Ramreddy, et al.
Publicado: (2014)

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K(+) solution: insights into the interconversion of human telomeric G-quadruplex structures
por: Zhang, Zhenjiang, et al.
Publicado: (2010)

Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation
por: Dai, Jixun, et al.
Publicado: (2007)

Editorial: NAR Cancer and epigenetics and cancer
por: Yang, Danzhou, et al.
Publicado: (2022)

Topoisomerase 1 inhibits MYC promoter activity by inducing G-quadruplex formation
por: Keller, Josephine Geertsen, et al.
Publicado: (2022)

Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K(+) solution
por: Phan, Anh Tuân, et al.
Publicado: (2006)

Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug—Design and Mechanism of Action
por: Buric, Adam J., et al.
Publicado: (2021)

Effects of Central Loop Length and Metal Ions on the Thermal Stability of G-Quadruplexes
por: Hao, Fengjin, et al.
Publicado: (2019)

Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
por: Ranjan, Nihar, et al.
Publicado: (2013)

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy
por: Bahls, Bárbara, et al.
Publicado: (2023)

Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
por: Ambrus, Attila, et al.
Publicado: (2006)

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
por: Marušič, Maja, et al.
Publicado: (2012)

G-Quadruplex loops regulate PARP-1 enzymatic activation
por: Edwards, Andrea D, et al.
Publicado: (2020)

G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
por: Miglietta, Giulia, et al.
Publicado: (2020)

G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
por: Miglietta, Giulia, et al.
Publicado: (2020)

Wild-type p53 binds to MYC promoter G-quadruplex
por: Petr, Marek, et al.
Publicado: (2016)

Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K(+) solution: insights into structure polymorphism of the human telomeric sequence
por: Dai, Jixun, et al.
Publicado: (2007)

Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi
por: Psaras, Alexandra Maria, et al.
Publicado: (2021)

Correction to article ‘G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders’
por: Miglietta, Giulia, et al.
Publicado: (2021)

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
por: Liu, Wenting, et al.
Publicado: (2018)

Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components
por: Fang, Shuyi, et al.
Publicado: (2022)

Effects of Length and Loop Composition on Structural Diversity and Similarity of (G(3)TG(3)N(m)G(3)TG(3)) G-Quadruplexes
por: Li, Jie, et al.
Publicado: (2020)

A Thermodynamic Perspective on Potential G‐Quadruplex Structures as Silencer Elements in the MYC Promoter
por: Jana, Jagannath, et al.
Publicado: (2020)

Exploring the Interaction of New Pyridoquinazoline Derivatives with G-Quadruplex in the c-MYC Promoter Region
por: Princiotto, Salvatore, et al.
Publicado: (2023)

Loop permutation affects the topology and stability of G-quadruplexes
por: Cheng, Mingpan, et al.
Publicado: (2018)

Effect of loop length variation on quadruplex-Watson Crick duplex competition
por: Kumar, Niti, et al.
Publicado: (2008)

HnRNPA1 Specifically Recognizes the Base of Nucleotide at the Loop of RNA G-Quadruplex
por: Liu, Xiao, et al.
Publicado: (2018)

Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex
por: Hao, Taisen, et al.
Publicado: (2016)

Effects of G-Quadruplex-Binding Plant Secondary Metabolites on c-MYC Expression
por: Zenkov, Roman G., et al.
Publicado: (2022)

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
por: Calabrese, David R., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_epj66ji7rjdopp78qra3erk7vg