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Pou5f3, SoxB1, and Nanog remodel chromatin on high nucleosome affinity regions at zygotic genome activation

The zebrafish embryo is transcriptionally mostly quiescent during the first 10 cell cycles, until the main wave of zygotic genome activation (ZGA) occurs, accompanied by fast chromatin remodeling. At ZGA, homologs of the mammalian stem cell transcription factors (TFs) Pou5f3, Nanog, and Sox19b bind...

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Detalles Bibliográficos
Autores principales: Veil, Marina, Yampolsky, Lev Y., Grüning, Björn, Onichtchouk, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396415/
https://www.ncbi.nlm.nih.gov/pubmed/30674556
http://dx.doi.org/10.1101/gr.240572.118