Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that cfDNA molecules are not randomly fragmented and possess information related to their tissues of origin. Pathologies causing death of cells fro...

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Detalles Bibliográficos
Autores principales: Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H.T., Wong, John, Wong, Vincent W.S., Ng, Simon S.M., Ma, Brigette B.Y., Leung, Tak Y., Chan, Stephen L., Mok, Tony S.K., Lai, Paul B.S., Chan, Henry L.Y., Sun, Hao, Chan, K.C. Allen, Chiu, Rossa W.K., Lo, Y.M. Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396422/
https://www.ncbi.nlm.nih.gov/pubmed/30808726
http://dx.doi.org/10.1101/gr.242719.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396422/
https://www.ncbi.nlm.nih.gov/pubmed/30808726
http://dx.doi.org/10.1101/gr.242719.118

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