Cargando…

Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses

BACKGROUND: Amlexanox (ALX), a TBK1 inhibitor, can modulate immune responses and has anti-inflammatory properties. To investigate its role in regulating the progression of experimental autoimmune encephalomyelitis (EAE), we studied the effect of ALX on the maturation of dendritic cells (DCs) and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quan, Mo-Yuan, Song, Xiu-Juan, Liu, Hui-Jia, Deng, Xiao-Hong, Hou, Hui-Qing, Chen, Li-Ping, Ma, Tian-Zhao, Han, Xu, He, Xin-Xin, Jia, Zhen, Guo, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396467/ https://www.ncbi.nlm.nih.gov/pubmed/30823934 http://dx.doi.org/10.1186/s12974-019-1438-z

Ejemplares similares

Rescue of nonsense mutations by amlexanox in human cells
por: Gonzalez-Hilarion, Sara, et al.
Publicado: (2012)

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells
por: Korniotis, Sarantis, et al.
Publicado: (2016)

Lineage Reprogramming of Effector Regulatory T Cells in Cancer
por: Dixon, Michael L., et al.
Publicado: (2021)

Artemisinin Analogue SM934 Ameliorates Murine Experimental Autoimmune Encephalomyelitis through Enhancing the Expansion and Functions of Regulatory T Cell
por: Li, Xin, et al.
Publicado: (2013)

Tolerogenic dendritic cells in experimental autoimmune encephalomyelitis, specific tolerance induction?
por: Sellés-Moreno, Carla, et al.
Publicado: (2012)

Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss
por: Zhang, Yong, et al.
Publicado: (2015)

Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
por: Abbasi, Farid, et al.
Publicado: (2016)

Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation
por: Yang, Huan-Li, et al.
Publicado: (2021)

A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial
por: Meng, Wenxia, et al.
Publicado: (2009)

MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells
por: Barbour, Mark, et al.
Publicado: (2016)

Apoptotic Cell Death in Experimental Autoimmune Encephalomyelitis: Apoptosis of effector cells as a safe mechanism in the termination of an autoimmune inflammatory attack
por: Chan, Andrew, et al.
Publicado: (2005)

Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
por: Kawakami, Naoto, et al.
Publicado: (2005)

Inhibition of experimental autoimmune encephalomyelitis by tolerance-promoting DNA vaccination focused to dendritic cells
por: Castor, Timo, et al.
Publicado: (2018)

Mature dendritic cells cause Th17/Treg imbalance by secreting TGF-β1 and IL-6 in the pathogenesis of experimental autoimmune encephalomyelitis
por: Lu, Pingxia, et al.
Publicado: (2016)

Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease
por: Dosanjh, Amrita, et al.
Publicado: (2020)

Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus
por: Domingues, Rosana, et al.
Publicado: (2016)

Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis
por: Thomé, Rodolfo, et al.
Publicado: (2013)

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis
por: Luo, Lin, et al.
Publicado: (2021)

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation
por: Zhang, Han, et al.
Publicado: (2017)

Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells
por: Weier, Ann-Kathrin, et al.
Publicado: (2022)

Maturation-Resistant Dendritic Cells Ameliorate Experimental Autoimmune Uveoretinitis
por: Oh, Keunhee, et al.
Publicado: (2011)

TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis
por: Mellanby, Richard J, et al.
Publicado: (2012)

Priming of myelin-specific T cells in the absence of dendritic cells results in accelerated development of Experimental Autoimmune Encephalomyelitis
por: Luu, Thaiphi, et al.
Publicado: (2021)

Induction of CD4(+) Regulatory and Polarized Effector/helper T Cells by Dendritic Cells
por: Lutz, Manfred B.
Publicado: (2016)

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance
por: Zhou, Yan, et al.
Publicado: (2016)

Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
por: Ferrara, Giovanni, et al.
Publicado: (2020)

Amlexanox and UPF1 Modulate Wnt Signaling and Apoptosis in HCT-116 Colorectal Cancer Cells
por: Bordonaro, Michael, et al.
Publicado: (2019)

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
por: Zhao, Peng, et al.
Publicado: (2022)

Dynamic metabolic reprogramming in dendritic cells: An early response to influenza infection that is essential for effector function
por: Rezinciuc, Svetlana, et al.
Publicado: (2020)

Lactobacillus acidipiscis Induced Regulatory Gamma Delta T Cells and Attenuated Experimental Autoimmune Encephalomyelitis
por: Ren, Saisai, et al.
Publicado: (2021)

CAR-T cells and CAR-Tregs targeting conventional type-1 dendritic cell suppress experimental autoimmune encephalomyelitis
por: Moorman, Cody D., et al.
Publicado: (2023)

Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
por: Zhang, Fei, et al.
Publicado: (2019)

Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells
por: Si, Chuanping, et al.
Publicado: (2016)

Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis
por: Vogel, Andrea, et al.
Publicado: (2022)

Kirenol Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Differentiation of Th1 and Th17 Cells and Inducing Apoptosis of Effector T Cells
por: Xiao, Juan, et al.
Publicado: (2015)

Amlexanox Blocks the Interaction between S100A4 and Epidermal Growth Factor and Inhibits Cell Proliferation
por: Cho, Ching Chang, et al.
Publicado: (2016)

Effector and regulatory dendritic cells display distinct patterns of miRNA expression
por: Lombardi, Vincent, et al.
Publicado: (2017)

The Regulatory Function of CCR9(+) Dendritic Cells in Inflammation and Autoimmunity
por: Pathak, Manisha, et al.
Publicado: (2020)

Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis
por: Korniotis, Sarantis, et al.
Publicado: (2020)

Regulatory and activated effector T cells in chronic hepatitis C virus: Relation to autoimmunity
por: Fouad, Hanan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_trpp1304t9koi7ttd4i1g57gkg