A G(s)-coupled purinergic receptor boosts Ca(2+) influx and vascular contractility during diabetic hyperglycemia

Elevated glucose increases vascular reactivity by promoting L-type Ca(V)1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a G(s)-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation during diabetic hyper...

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Detalles Bibliográficos
Autores principales: Prada, Maria Paz, Syed, Arsalan U, Buonarati, Olivia R, Reddy, Gopireddy R, Nystoriak, Matthew A, Ghosh, Debapriya, Simó, Sergi, Sato, Daisuke, Sasse, Kent C, Ward, Sean M, Santana, Luis F, Xiang, Yang K, Hell, Johannes W, Nieves-Cintrón, Madeline, Navedo, Manuel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397001/
https://www.ncbi.nlm.nih.gov/pubmed/30821687
http://dx.doi.org/10.7554/eLife.42214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397001/
https://www.ncbi.nlm.nih.gov/pubmed/30821687
http://dx.doi.org/10.7554/eLife.42214

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