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Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0(ΔC/ΔC) Mice
PURPOSE: Investigate the effects of the absence of 17 amino acids at the C-terminal end of Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. METHODS: A knockin (KI) mouse model (AQP0(ΔC/ΔC)) was developed to express AQP0 only as the end-cleaved form in the lens. For this,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Association for Research in Vision and Ophthalmology
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397018/ https://www.ncbi.nlm.nih.gov/pubmed/30821811 http://dx.doi.org/10.1167/iovs.18-26378 |