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The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns
During the evolution of multicellular eukaryotes, gene duplication occurs frequently to generate new genes and/or functions. A duplicated gene may have a similar function to its ancestral gene. Therefore, it may be expected that duplicated genes are less likely to be critical for the survival of an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397145/ https://www.ncbi.nlm.nih.gov/pubmed/30824779 http://dx.doi.org/10.1038/s41598-019-39894-9 |
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author | Kabir, Mitra Wenlock, Stephanie Doig, Andrew J. Hentges, Kathryn E. |
author_facet | Kabir, Mitra Wenlock, Stephanie Doig, Andrew J. Hentges, Kathryn E. |
author_sort | Kabir, Mitra |
collection | PubMed |
description | During the evolution of multicellular eukaryotes, gene duplication occurs frequently to generate new genes and/or functions. A duplicated gene may have a similar function to its ancestral gene. Therefore, it may be expected that duplicated genes are less likely to be critical for the survival of an organism, since there are multiple copies of the gene rendering each individual copy redundant. In this study, we explored the developmental expression patterns of duplicate gene pairs and the relationship between development co-expression and phenotypes resulting from the knockout of duplicate genes in the mouse. We define genes that generate lethal phenotypes in single gene knockout experiments as essential genes. We found that duplicate gene pairs comprised of two essential genes tend to be expressed at different stages of development, compared to duplicate gene pairs with at least one non-essential member, showing that the timing of developmental expression affects the ability of one paralogue to compensate for the loss of the other. Gene essentiality, developmental expression and gene duplication are thus closely linked. |
format | Online Article Text |
id | pubmed-6397145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63971452019-03-05 The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns Kabir, Mitra Wenlock, Stephanie Doig, Andrew J. Hentges, Kathryn E. Sci Rep Article During the evolution of multicellular eukaryotes, gene duplication occurs frequently to generate new genes and/or functions. A duplicated gene may have a similar function to its ancestral gene. Therefore, it may be expected that duplicated genes are less likely to be critical for the survival of an organism, since there are multiple copies of the gene rendering each individual copy redundant. In this study, we explored the developmental expression patterns of duplicate gene pairs and the relationship between development co-expression and phenotypes resulting from the knockout of duplicate genes in the mouse. We define genes that generate lethal phenotypes in single gene knockout experiments as essential genes. We found that duplicate gene pairs comprised of two essential genes tend to be expressed at different stages of development, compared to duplicate gene pairs with at least one non-essential member, showing that the timing of developmental expression affects the ability of one paralogue to compensate for the loss of the other. Gene essentiality, developmental expression and gene duplication are thus closely linked. Nature Publishing Group UK 2019-03-01 /pmc/articles/PMC6397145/ /pubmed/30824779 http://dx.doi.org/10.1038/s41598-019-39894-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kabir, Mitra Wenlock, Stephanie Doig, Andrew J. Hentges, Kathryn E. The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title | The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title_full | The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title_fullStr | The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title_full_unstemmed | The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title_short | The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns |
title_sort | essentiality status of mouse duplicate gene pairs correlates with developmental co-expression patterns |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397145/ https://www.ncbi.nlm.nih.gov/pubmed/30824779 http://dx.doi.org/10.1038/s41598-019-39894-9 |
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