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Myocardial lipofuscin accumulation in ageing and sudden cardiac death

Lipofuscin is an intracellular aggregate of highly oxidized proteins that cannot be digested in the ubiquitin-proteasome system and accumulate mainly in lysosomes, especially in aged cells and pathological conditions. However, no systematic study has evaluated the cardiac accumulation of lipofuscin...

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Detalles Bibliográficos
Autores principales: Kakimoto, Yu, Okada, Chisa, Kawabe, Noboru, Sasaki, Ayumi, Tsukamoto, Hideo, Nagao, Ryoko, Osawa, Motoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397159/
https://www.ncbi.nlm.nih.gov/pubmed/30824797
http://dx.doi.org/10.1038/s41598-019-40250-0