Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance

6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP(+) as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles...

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Detalles Bibliográficos
Autores principales: Liu, Ruilong, Li, Wenfeng, Tao, Bangbao, Wang, Xiongjun, Yang, Zhuo, Zhang, Yajuan, Wang, Chenyao, Liu, Rongzhi, Gao, Hong, Liang, Ji, Yang, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397164/
https://www.ncbi.nlm.nih.gov/pubmed/30824700
http://dx.doi.org/10.1038/s41467-019-08921-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397164/
https://www.ncbi.nlm.nih.gov/pubmed/30824700
http://dx.doi.org/10.1038/s41467-019-08921-8

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