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Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance

6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP(+) as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles...

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Detalles Bibliográficos
Autores principales:	Liu, Ruilong, Li, Wenfeng, Tao, Bangbao, Wang, Xiongjun, Yang, Zhuo, Zhang, Yajuan, Wang, Chenyao, Liu, Rongzhi, Gao, Hong, Liang, Ji, Yang, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397164/ https://www.ncbi.nlm.nih.gov/pubmed/30824700 http://dx.doi.org/10.1038/s41467-019-08921-8

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