Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. Enhancement of P2X7 receptor responses may be useful in pathogen clearance particularly in individuals with defective mic...

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Detalles Bibliográficos
Autores principales: Bidula, Stefan M., Cromer, Brett A., Walpole, Samuel, Angulo, Jesus, Stokes, Leanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397193/
https://www.ncbi.nlm.nih.gov/pubmed/30824738
http://dx.doi.org/10.1038/s41598-019-39771-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397193/
https://www.ncbi.nlm.nih.gov/pubmed/30824738
http://dx.doi.org/10.1038/s41598-019-39771-5

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