Mutations in DNA repair genes are associated with increased neoantigen burden and a distinct immunophenotype in lung squamous cell carcinoma

Deficiencies in DNA repair pathways, including mismatch repair (MMR), have been linked to higher tumor mutation burden and improved response to immune checkpoint inhibitors. However, the significance of MMR mutations in lung cancer has not been well characterized, and the relevance of other processe...

Descripción completa

Detalles Bibliográficos
Autores principales: Chae, Young Kwang, Anker, Jonathan F., Oh, Michael S., Bais, Preeti, Namburi, Sandeep, Agte, Sarita, Giles, Francis J., Chuang, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397194/
https://www.ncbi.nlm.nih.gov/pubmed/30824826
http://dx.doi.org/10.1038/s41598-019-39594-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397194/
https://www.ncbi.nlm.nih.gov/pubmed/30824826
http://dx.doi.org/10.1038/s41598-019-39594-4

Ejemplares similares