Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1(G93A) Model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early pathological events in ALS include perturbations in axonal transport (AT), formation of toxic protein aggregates and...

Descripción completa

Detalles Bibliográficos
Autores principales: Ionescu, Ariel, Gradus, Tal, Altman, Topaz, Maimon, Roy, Saraf Avraham, Noi, Geva, Michal, Hayden, Michael, Perlson, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397200/
https://www.ncbi.nlm.nih.gov/pubmed/30824685
http://dx.doi.org/10.1038/s41419-019-1451-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397200/
https://www.ncbi.nlm.nih.gov/pubmed/30824685
http://dx.doi.org/10.1038/s41419-019-1451-2

Ejemplares similares