Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase

This study demonstrated that fenofibrate, a lipid-lowering drug, induced a significant time-dependent cytotoxicity of hepatoma Hep3B cells. Hep3B cells are significantly more sensitive to cell killing by fenofibrate than hepatoma HepG2, lung cancer CH27 and oral cancer HSC-3 cells. From the result o...

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Detalles Bibliográficos
Autores principales: You, Bang-Jau, Hour, Mann-Jen, Chen, Li-Yun, Luo, Shu-Ching, Hsu, Po-Hsiang, Lee, Hong-Zin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397239/
https://www.ncbi.nlm.nih.gov/pubmed/30824767
http://dx.doi.org/10.1038/s41598-019-39778-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397239/
https://www.ncbi.nlm.nih.gov/pubmed/30824767
http://dx.doi.org/10.1038/s41598-019-39778-y

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