Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes can become dispensable for viability remain unclear. Here, we investigate ‘bypass of essentiality (BOE)’ — an underexplored type of digenic genetic interaction that renders essential genes dispensable. Throu...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jun, Wang, Hai-Tao, Wang, Wei-Tao, Zhang, Xiao-Ran, Suo, Fang, Ren, Jing-Yi, Bi, Ying, Xue, Ying-Xi, Hu, Wen, Dong, Meng-Qiu, Du, Li-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397241/
https://www.ncbi.nlm.nih.gov/pubmed/30824696
http://dx.doi.org/10.1038/s41467-019-08928-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397241/
https://www.ncbi.nlm.nih.gov/pubmed/30824696
http://dx.doi.org/10.1038/s41467-019-08928-1

Ejemplares similares