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Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
Gene essentiality is a variable phenotypic trait, but to what extent and how essential genes can become dispensable for viability remain unclear. Here, we investigate ‘bypass of essentiality (BOE)’ — an underexplored type of digenic genetic interaction that renders essential genes dispensable. Throu...
Autores principales: | Li, Jun, Wang, Hai-Tao, Wang, Wei-Tao, Zhang, Xiao-Ran, Suo, Fang, Ren, Jing-Yi, Bi, Ying, Xue, Ying-Xi, Hu, Wen, Dong, Meng-Qiu, Du, Li-Lin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397241/ https://www.ncbi.nlm.nih.gov/pubmed/30824696 http://dx.doi.org/10.1038/s41467-019-08928-1 |
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