NFAT1 protects articular cartilage against osteoarthritic degradation by directly regulating transcription of specific anabolic and catabolic genes

OBJECTIVES: Adult mice lacking the transcription factor NFAT1 exhibit osteoarthritis (OA). The precise molecular mechanism for NFAT1 deficiency-induced osteoarthritic cartilage degradation remains to be clarified. This study aimed to investigate if NFAT1 protects articular cartilage (AC) against OA...

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Detalles Bibliográficos
Autores principales: Zhang, M., Lu, Q., Budden, T., Wang, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397328/
https://www.ncbi.nlm.nih.gov/pubmed/30915215
http://dx.doi.org/10.1302/2046-3758.82.BJR-2018-0114.R1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397328/
https://www.ncbi.nlm.nih.gov/pubmed/30915215
http://dx.doi.org/10.1302/2046-3758.82.BJR-2018-0114.R1

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