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Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer

SMAD2 and SMAD3 are downstream proteins in the transforming growth factor-β (TGF β) signaling pathway that translocate signals from the cell membrane to the nucleus, bind DNA, and control the expression of target genes. While SMAD2/3 have important roles in the ovary, we do not fully understand the...

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Detalles Bibliográficos
Autores principales: Kriseman, Maya, Monsivais, Diana, Agno, Julio, Masand, Ramya P., Creighton, Chad J., Matzuk, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397514/
https://www.ncbi.nlm.nih.gov/pubmed/30651315
http://dx.doi.org/10.1073/pnas.1806862116