Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice

One of the strongest susceptibility genes for age-related macular degeneration (AMD) is complement factor H (CFH); however, its impact on AMD pathobiology remains unresolved. Here, the effect of the principal AMD-risk–associated CFH variant (Y402H) on the development and progression of age-dependent...

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Detalles Bibliográficos
Autores principales: Landowski, Michael, Kelly, Una, Klingeborn, Mikael, Groelle, Marybeth, Ding, Jin-Dong, Grigsby, Daniel, Bowes Rickman, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397537/
https://www.ncbi.nlm.nih.gov/pubmed/30808757
http://dx.doi.org/10.1073/pnas.1814014116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397537/
https://www.ncbi.nlm.nih.gov/pubmed/30808757
http://dx.doi.org/10.1073/pnas.1814014116

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