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HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission

Human cytomegalovirus (HCMV) causes substantial disease in transplant patients and harms the development of the nervous system in babies infected in utero. Thus, there is a major focus on developing safe and effective HCMV vaccines. Evidence has been presented that a major target of neutralizing ant...

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Detalles Bibliográficos
Autores principales: Vanarsdall, Adam L., Chin, Andrea L., Liu, Jing, Jardetzky, Theodore S., Mudd, James O., Orloff, Susan L., Streblow, Daniel, Mussi-Pinhata, Marisa M., Yamamoto, Aparecida Y., Duarte, Geraldo, Britt, William J., Johnson, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397592/
https://www.ncbi.nlm.nih.gov/pubmed/30733288
http://dx.doi.org/10.1073/pnas.1814835116