The tuberculosis necrotizing toxin is an NAD(+) and NADP(+) glycohydrolase with distinct enzymatic properties

Upon host infection, Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) into the cytosol of infected macrophages, leading to host cell death by necroptosis. TNT hydrolyzes NAD(+) in the absence of any exogenous cofactor, thus classifying it as a β-NAD(+) glycohydrolase. How...

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Detalles Bibliográficos
Autores principales: Tak, Uday, Vlach, Jiri, Garza-Garcia, Acely, William, Doreen, Danilchanka, Olga, de Carvalho, Luiz Pedro Sório, Saad, Jamil S., Niederweis, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398120/
https://www.ncbi.nlm.nih.gov/pubmed/30593509
http://dx.doi.org/10.1074/jbc.RA118.005832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398120/
https://www.ncbi.nlm.nih.gov/pubmed/30593509
http://dx.doi.org/10.1074/jbc.RA118.005832

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