The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation

Kinesin-13 motors regulate precise microtubule dynamics and limit microtubule length throughout metazoans by depolymerizing microtubule ends. Recently, the kinesin-13 motor family member MCAK (also known Kif2C) has been proposed to undergo large conformational changes during its catalytic cycle, as...

Descripción completa

Detalles Bibliográficos
Autores principales: McHugh, Toni, Zou, Juan, Volkov, Vladimir A., Bertin, Aurélie, Talapatra, Sandeep K., Rappsilber, Juri, Dogterom, Marileen, Welburn, Julie P. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398471/
https://www.ncbi.nlm.nih.gov/pubmed/30578316
http://dx.doi.org/10.1242/jcs.228353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398471/
https://www.ncbi.nlm.nih.gov/pubmed/30578316
http://dx.doi.org/10.1242/jcs.228353

Ejemplares similares