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Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease

Endoplasmic reticulum (ER) stress has been causatively linked to the onset of various pathologies. However, whether and how inherent variations in the resulting unfolded protein response (UPR) affect predisposition to ER-stress-associated metabolic conditions remains to be established. By using gene...

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Detalles Bibliográficos
Autores principales: Havighorst, Amanda, Zhang, Youwen, Farmaki, Elena, Kaza, Vimala, Chatzistamou, Ioulia, Kiaris, Hippokratis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398494/
https://www.ncbi.nlm.nih.gov/pubmed/30733237
http://dx.doi.org/10.1242/dmm.037242