A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion

Altered molecular responses to insulin and growth factors (GF) are responsible for late‐life shortening diseases such as type‐2 diabetes mellitus (T2DM) and cancers. We have built a network of the signaling pathways that control S‐phase entry and a specific type of senescence called geroconversion....

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Detalles Bibliográficos
Autores principales: Verlingue, Loic, Dugourd, Aurélien, Stoll, Gautier, Barillot, Emmanuel, Calzone, Laurence, Londoño‐Vallejo, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398530/
https://www.ncbi.nlm.nih.gov/pubmed/27613445
http://dx.doi.org/10.1111/acel.12504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398530/
https://www.ncbi.nlm.nih.gov/pubmed/27613445
http://dx.doi.org/10.1111/acel.12504

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