Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension

OBJECTIVE: Non-selective histone deacetylase (HDAC) inhibitors are known to improve hypertension. Here, we investigated the therapeutic effect and regulatory mechanism of the class I HDAC selective inhibitors, MS-275 and RGFP966, in angiotensin (Ang) II-induced hypertensive mice. METHODS AND RESULTS...

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Detalles Bibliográficos
Autores principales: Ryu, Yuhee, Kee, Hae Jin, Sun, Simei, Seok, Young Mi, Choi, Sin Young, Kim, Gwi Ran, Kee, Seung-Jung, Pflieger, Marc, Kurz, Thomas, Kim, Hyung-Seok, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398866/
https://www.ncbi.nlm.nih.gov/pubmed/30830950
http://dx.doi.org/10.1371/journal.pone.0213186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398866/
https://www.ncbi.nlm.nih.gov/pubmed/30830950
http://dx.doi.org/10.1371/journal.pone.0213186

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